AVAILABLE POSITIONS AND TOPICS 2023

Maladaptive expression of memory as important determinant of Post-Traumatic Disorders 

Requirements The ideal candidate is already expert in most molecular biology techniques. Preferential skills include experience with in vivo experiments, behavioural analyses and pharmacological approaches.

Combined pharmacological approaches for neural tissue regeneration

Requirements Any experience in molecular biology, biochemistry, cell culture, cell metabolism is an advantage. Motivated students with a strong commitment to basic and translational research are invited to apply. The candidate should have well-developed social skills, a hands-on attitude and be able to work in a team.

Whole Exome Sequencing and functional validation in Zebrafish model to uncover new targets genes responsible for GnRH neuron development defects

Requirements Eventual experience on endocrine regulatory mechanisms of reproduction, whole exome sequencing technique and analysis, molecular biology techniques for gene expression studies, zebrafish model and pluripotent stem cells

Identification of novel strategies targeting macrophages in immune response to tumors  

Requirements Basic cellular and molecular biology; biochemical competences. Possible (not mandatory) in vivo experience

Organoids as a tool for personalized medicine       

Requirements Cell culture, Western Blotting, Nucleic acids extraction, Real-Time PCR, gene silencing.

Role and potential of tumor-derived extracellular vesicles            

Requirements Basic molecular and cellular biology techniques. Expertise in extracellular vesicle analysis and flow cytometry technique represent an added value.

The Molecular Mechanisms of Obesity associated to Cardiac Remodeling   

Requirements Basic practice in molecular biology: RT-PCR; RNA/DNA extraction; Tissue Protein extraction; 2D Cell culture management

Impact of endothelial dysfunctions in the pathogenesis of antiphospholipid syndrome-associated thrombosis

Requirement Basic experience in cell culture techniques, flow cytometry, confocal microscopy, molecular biology and related computational analytical approaches. Willingness to spend periods abroad for training and collaborations.

New combination of micro-dystrophin and mitochondrial-based therapy to promote muscle regeneration in Duchenne Muscular Dystrophy

Requirement: none

Dipeptidyl Peptidase-4 (DPP4) inhibition: role in obesity-induced inflammation and tissue injury

Requirements Knowledge of the main techniques of cellular and molecular biology [cell cultures, gene silencing, gene and protein expression analysis), biochemical assays for the evaluation of biomarkers in fluids and histochemistry.

The role of PHOX2B in the differentiation and function of sympathetic neurons, in health and disease, by using human-derived iPSCs: the case of Congenital Central Hypoventilation Syndrome      

Requirements Basic cellular and molecular biology techniques (PCR, RNA extraction, RT-qPCR, western blot), mammalian cell culture and immunofluorescence.

Analysis of GABAergic circuitry in Pcdh19 mouse model of Developmental and epileptic encephalopathy 9 (DEE9)

Requirements Students should be interested in the investigation of new therapeutic strategies to target DMD, focusing on the setting of preclinical studies in DMD models to test the impact of the new interventions proposed.

Study of cell-to-cell crosstalk in Rett syndrome: focus on the interactions between astrocytes and synapses

Requirements Basic knowledge of molecular and cellular biology, neurobiology

Molecular, cellular and functional characterization of Haus7 a new potential molecular determinant in neuronal maturation and neurodevelopmental disorders

Requirements Previous experience in molecular biology and/or cellular biology and/or imaging will represent a useful support for the candidate.

Role of IL7-R+ monocytes in infective and tumoral settings          

Requirements Basic cellular and molecular biology

Molecular and spatial analysis of granulomatous reaction in human diseases.                      

Requirement: none

Exploring Immuno-Regulatory Mechanisms in the Tumor Microenvironment to Treat Ovarian Cancer.           

Requirements Basic experience/knowledge of molecular and cellular biology techniques. Knowledge of flow cytometry will be an advantage. Availability of spending periods abroad for training and collaborations. Experience in immunology or medicine biology will be preferred.

Involvement of microglial cells in the etiology, neurobiology and treatment of stress-related psychiatric disorders

Requirements Expertise in gene and protein expression analyses, cell culture.

Advanced understanding of Thyroid Hormone action in brain and heart using Zebrafish model and induced pluripotent stem cells (iPSC)

Requirements Experience in molecular biology and cellular cultures

Zebrafish (danio rerio) as a model to study the mechanisms underlying human disease and tool for therapeutic strategies             

Requirements Expertise in cellular and molecular biology

Patient-derived iPSC to dissect pathomechanisms with 2D and 3D models of ALS motoneuron disease

Requirements Expertise in cell culture (iPSC) and/or in molecular biology techniques is preferential together with high motivation.

Unraveling mechanism(s) of interaction between tumor cells and microenvironment components relevant for triple negative breast cancer progression

Requirement: none

Adipo-NETwork: inside the crosstalk between adipose cells and gastroenteropancreatic neuroendocrine tumors (GEP-NETs)        

Requirements Strong interest for basic and translational research.