Characterization of GABAergic circuitries in the pathogenesis of Developmental and Epileptic Encephalopathy 9

Exploring the therapeutic potential of histone deacetylase, both as single-agent treatments and in combination with other drugs and investigate the molecular mechanisms associated with their regulation in different pathological conditions.

Establishing iPSC-based 2D and 3D neuronal models to study possible neurodevelopmental defects in Congenital Central Hypoventilation Syndrome.

To study and to manipulate the alternative splicing of the insulin receptor in adrenocortical carcinoma, a rare malignant tumour, and to evaluate the in vitro and in vivo downstream effects of this manipulation.

Development RNA therapies for the treatment of neurodevelopmental disorders, focusing on RETT syndrome and CDKL5 Deficiency Disorder.

Investigating altered molecular mechanisms in human diseases, focusing on glioblastoma and taking advantage of both in vivo and in vitro approaches.

Exploring the molecular mechanisms underlying the pathogenesis of Cerebral Cavernous Malformations (CCM), a rare genetic neurovascular disease, with the ultimate goal to define and test potential therapeutic avenues on in vitro and in vivo models of the disease.

Sociotechnical construction of “NeuroCOVID” as a disease category through omics data analysis and qualitative research methods.

Innate Immune Cells (NK cells and ILCs) in hematologic malignancies – mainly myelodysplastic syndromes- also in response to therapeutic interventions, aiming to investigate their involvement in disease pathogenesis and progression.

To investigate the astrocyte-neuron interaction in the pathogenesis of Rett syndrome, focusing in particular on the role of astrocyte-derived extracellular vescicles.

Finding personalized approaches and treatments for neurodevelopmental disorders, utilizing electrophysiological, in vivo, and in vitro techniques.

To identify and characterize immune cells profiles by exploiting multidimensional tissue analysis in several pathological settings such as pancreatic cancer.

Studying RNA modifications on tumor proliferation via high-throughput CRISPR base editing screening.

Studying the immune system through the analysis of single-cell RNA sequencing (scRNA-seq) data, utilizing bioinformatics tools and computational approaches.

Study of Congenital Central Hypoventilation Syndrome, in particular the role of PHOX 2 B in differentiation of patient derived iPSC neurons

Characterization of the     role and mechanisms  of endothelial dysfunction in patients with antiphospholypid syndrome.

Cell metabolism modulation for the development of a new therapeutical approach in regenerative medicine field for the nervous tissue

Study of pathomechanisms related to TARDBP gene in amyotrophic lateral sclerosis (ALS) using patient-derived iPSC models.

The beneficial effects of persistent Sirtuin1 activation in dystrophic muscles and at exploring the synergic effects of the combination between micro-dystrophin gene therapy and Sirtuin1 activation.

The characterization and the preclinical validation of a novel epigenetic target in the treatment of Post-Traumatic Stress Disorder.

The application of artificial intelligence tools for the analysis of tumor tissues to study the cellular composition and the spatial organization of the tumor microenvironment.

Understanding the physiological role of Haus7 in neuronal maturation and its potential role as modifier gene of Rett syndrome.

The role of the recently identified organelle named paraspeckle and its protein components in Multiple  Myeloma pathogenesis

3 D culture system of human organoids, in particular, mini guts from patient exosomes to personalize therapy in  Crohn’s disease

Immunopathogenesis of thymic epithelial tumors and related autoimmune diseases

Characterization of the molecular circuits that define the function of regulatory CD4 T lymphocytes

Priming strategies to enhance the effect of the secretome of mesenchymal stem/stromal cells in counteracting osteoarthritis through the action of EVs

Role of oxidative stress in vulnerability to psychiatric diseases and in the mechanism of action of psychotropic drugs

The zebrafish model as a means to validate the role of new pathogenic mechanisms and potential treatments for high-impact congenital diseases

Correction of the genetic defect in induced pluripotent stem cell lines through chromosome transplantation

Study of the escape mechanisms of metastatic colorectal cancer from immunological surveillance.

Integrating pharmacogenomic and pharmacometabolomic data for personalized opioid therapy for advanced cancer pain

Molecular mechanisms regulating the Insulin-like Growth Factor (IGF) system in adrenal carcinomas

Study of the effect of Tumor Educated Macrophages on neural cells (Ex DM 352/2022)

Identification and characterization of new modifier genes of Rett syndrome

New regulatory mechanisms of macrophage function: the role of MS4A proteins

Single-cell CRISPR pooled screening to dissect gene–function relations in colo-rectal cancer derived organoids.

Zebrafish (danio rerio) as a model system for the functional validation of candidate genes in human diseases.

Aggregation mechanisms of TDP-43 protein in response to stress in amyotrophic lateral sclerosis and therapeutic approaches

Innate immunity and tumour escape mechanisms in the prognosis and therapy of ovarian and uterine cancers

Use of induced pluripotent stem cells iPS for the study of Autonomic Nervous System (ANS) disease: focus on Congenital Central Hypoventilation Syndrome.

Stimulating neuronal activity in Mecp2 deficient brain to improve typical symptoms of Rett syndrome

Role of innate immunity in the pathogenesis of primary biliary cholangitis

Combined pharmacological approaches for spinal cord injury regeneration

Development of novel therapeutic approaches to aggressive thyroid cancers, in vivo and in vitro studies

Role of endothelial dysfunction in the pathogenesis of unprovoked venous thromboembolism

Dissecting the pathogenetic role of deregulated non-coding transcripts associated with DIS3 gene mutations in Multiple Myeloma

Multicellular spheroids: a new model for thyroid cancer studies and drug screening. 

Novel macrophage tetraspan molecules: biological relevance immune responses and therapeutic exploitation

The interplay between cellular aging and immune response in human colorectal liver metastasis: senescence as a new prognostic marker?

Neural stem precursor cell therapy: a novel therapeutic approach for the treatment of Rett syndrome

Investigation of pathomechanisms associated to amyotrophic lateral sclerosis in patient-derived cells

Obesity and cardiovascular disease: the role of the receptor for advanced glycation end products (RAGE) in heart steatosis

Molecular mechanisms underlying the association between psychiatric disorders and inflammation as potential pharmacological targets

Epigenetic characterization of tumor infiltrating CD4+ regulatory T cells

Pattern of innate immunity response in patients affected by myelodysplastic syndrome (MDS) either before and after hematopoietic stem cell transplant (HSCT)

Involvement of ATM and ATR in the regulation of the central nervous system development

In vitro cross-talk between osteosarcoma (OS) cells and mesenchymal stem/stromal cells (MSC): lipidomic analysis of Evs derived from both MSC- and OS- cells

Unravel the mechanisms tuning neuronal network electrical properties in ALS

Extracellular vesicles-mediated communication in remodeling multiple myeloma microenvironment: a new role for the Notch pathway

Solving the puzzle of protocadherin-19 mosaicism to understand the pathophysiology of PCDH19 Female Epilepsy (PCDH19-FE)

Zebrafish as a model to study common molecular mechanisms involved in cancer and neurodegenerative diseases

Zebrafish: an innovative model for neuroendocrine tumors.

Endothelium in Petri dish (2D) or on a chip (3D): studies on endothelial function/dysfunction